Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.

Inclusion Criteria:

1. Age between 18~70,both gender.

2. Patients with upper gastrointestinal symptoms and with documented H.pylori infectionwho did not receive Helicobacter pylori eradication treatment;

3. Patients are willing to receive eradication treatment.

4. Women of childbearing age were required to use medically acceptable contraceptivemethods during and 30 days after the trial.

Exclusion Criteria:

1. Patients are excluded if they have previously used antibiotics to eradicateadequately recorded infection with H. pylori.

2. Patients with contraindications or allergies to the study drug.

3. Severe organ damage and complications (such as liver cirrhosis, uremia, etc.),severe or unstable cardiopulmonary or endocrine diseases.

4. Constant use of anti-ulcer drugs ( including taking proton-pump.inhibitors(PPI)within 2 weeks before the [13C] urea breath test),antibiotics or bismuth complexes (more than 3 times /1 month before screening).

5. Patients were diagnosed with gastroduodenal ulcer and MALTlymphoma.

6. Pregnant or lactating women.

7. Underwent upper gastrointestinal Surgery.

8. Patients with moderate to severe dysplasia or high degree of intraepithelialneoplasia.

9. Patients have symptom of dysphagia.

10. Evidence of bleeding or iron efficiency anemia.

11. A history of malignancy.

12. Drug or alcohol abuse history in the past 1 year.

13. Systemic use of corticosteroids, non steroidal anti-inflammatorydrugs,anticoagulants, platelet aggregation inhibitors (except the use of aspirin forless than 100 mg/d).

14. Patients who has psychological problem or poor compliance.

15. Enrolled in other clinical trials in the past 3 months.

16. Refuse to sign informed consent.