A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity

Last updated: April 17, 2025
Sponsor: Eli Lilly and Company
Overall Status: Active - Not Recruiting

Phase

3

Condition

Obesity

Diabetes Prevention

Treatment

Retatrutide

Tirzepatide

Clinical Study ID

NCT06662383
18585
2024-511450-49-00
J1I-MC-GZBP
  • Ages > 18
  • All Genders

Study Summary

The main purpose of this study is to evaluate the efficacy and safety of retatrutide compared to tirzepatide in adults who have obesity. The study will last about 89 weeks.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have obesity and a history of at least one self-reported unsuccessful dietary effortto reduce body weight.

Exclusion

Exclusion Criteria:

  • Have a self-reported change in body weight >5 kilograms (kg) (11 pounds) within 90days before screening.

  • Have a prior or planned surgical treatment for obesity.

  • Have a prior or planned endoscopic procedure and/or device-based therapy forobesity.

  • Have taken weight loss drugs, including over-the-counter medications, within 90 daysprior to screening.

  • Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2).

  • Have had within the past 90 days before screening:

  • acute myocardial infarction

  • cerebrovascular accident (stroke)

  • coronary revascularization

  • hospitalization for unstable angina, or

  • hospitalization due to congestive heart failure.

  • Have New York Heart Association Functional Classification Class IV congestive heartfailure.

  • Have a history of chronic or acute pancreatitis.

Study Design

Total Participants: 800
Treatment Group(s): 2
Primary Treatment: Retatrutide
Phase: 3
Study Start date:
November 01, 2024
Estimated Completion Date:
April 30, 2027

Connect with a study center

  • DIM Clínica Privada

    Ramos Mejía, Buenos Aires B1704ETD
    Argentina

    Site Not Available

  • Centro Médico Viamonte

    Buenos Aires, Ciudad Autónoma De Buenos Aires C1120AAC
    Argentina

    Site Not Available

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires C1425AGC
    Argentina

    Site Not Available

  • Consultorio de Investigación Clínica EMO SRL

    Ciudad Autonoma de Buenos Aires, Ciudad Autónoma De Buenos Aires C1405BUB
    Argentina

    Site Not Available

  • Centro de Investigaciones Metabólicas (CINME)

    Ciudad Autónoma de Buenos Aires, C1056ABI
    Argentina

    Site Not Available

  • Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob

    Villingen-Schwenningen, Baden-Württemberg 78048
    Germany

    Site Not Available

  • Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz

    Lingen, Niedersachsen 49808
    Germany

    Site Not Available

  • InnoDiab Forschung Gmbh

    Essen, Nordrhein-Westfalen 45136
    Germany

    Site Not Available

  • Medizentrum Essen Borbeck

    Essen, Nordrhein-Westfalen 45355
    Germany

    Site Not Available

  • Zentrum fur klinische Forschung - Köln

    Köln, Nordrhein-Westfalen 51069
    Germany

    Site Not Available

  • AmBeNet GmbH

    Leipzig, Sachsen 04107
    Germany

    Site Not Available

  • RED-Institut GmbH

    Oldenburg, Schleswig-Holstein 23758
    Germany

    Site Not Available

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109
    Germany

    Site Not Available

  • Diabeteszentrum Hamburg West

    Hamburg, 22607
    Germany

    Site Not Available

  • Ekamed

    Lublin, Lubelskie 20-718
    Poland

    Site Not Available

  • Gabinety TERPA

    Lublin, Lubelskie 20-333
    Poland

    Site Not Available

  • Gabinet Leczenia Otylosci i Chorob Dietozaleznych - dr hab. n. med. Lucyna Ostrowska

    Bialystok, Podlaskie 15-281
    Poland

    Site Not Available

  • NZOZ Specjalistyczny Ośrodek Internistyczno-Diabetologiczny

    Bialystok, Podlaskie 15-435
    Poland

    Site Not Available

  • Zdrowie Osteo-Medic

    Bialystok, Podlaskie 15-351
    Poland

    Site Not Available

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Białystok, Podlaskie 15-276
    Poland

    Site Not Available

  • Nzoz Neuro-Kard Ilkowski i Partnerzy SPL

    Poznan, Wielkopolskie 61-853
    Poland

    Site Not Available

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznań, Wielkopolskie 60-589
    Poland

    Site Not Available

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, Łódzkie 90-338
    Poland

    Site Not Available

  • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

    Ruda Slaska, Śląskie 41-709
    Poland

    Site Not Available

  • Ponce Medical School Foundation Inc.

    Ponce, 00716
    Puerto Rico

    Site Not Available

  • Medical Advancement Centers of Arizona

    Tempe, Arizona 85283
    United States

    Site Not Available

  • Mary & Dick Allen Diabetes Center

    Newport Beach, California 92663
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego, California 92103
    United States

    Site Not Available

  • Encompass Clinical Research

    Spring Valley, California 91978
    United States

    Site Not Available

  • Diablo Clinical Research, Inc.

    Walnut Creek, California 94598
    United States

    Site Not Available

  • Lynn Institute of Denver

    Aurora, Colorado 80012
    United States

    Site Not Available

  • Bridgeport Hospital

    Bridgeport, Connecticut 06610
    United States

    Site Not Available

  • Yale University School of Medicine

    New Haven, Connecticut 06519
    United States

    Site Not Available

  • Encore Medical Research

    Hollywood, Florida 33024
    United States

    Site Not Available

  • Onhealth Research Center

    Miami, Florida 33186
    United States

    Site Not Available

  • Suncoast Research Group

    Miami, Florida 33135
    United States

    Site Not Available

  • Precision Clinical Research

    Sunrise, Florida 33351
    United States

    Site Not Available

  • Einstein Clinical Research

    Vero Beach, Florida 32960
    United States

    Site Not Available

  • ClinCept Clinical Research - MH

    Columbus, Georgia 31904
    United States

    Site Not Available

  • Northeast Georgia Medical Center

    Gainesville, Georgia 30501
    United States

    Site Not Available

  • Pivotal Research Solutions

    Stonecrest, Georgia 30038
    United States

    Site Not Available

  • East-West Medical Research Institute

    Honolulu, Hawaii 96814
    United States

    Site Not Available

  • Northwestern University

    Chicago, Illinois 60611
    United States

    Site Not Available

  • Integrated Clinical Trial Services, Inc.

    West Des Moines, Iowa 50265
    United States

    Site Not Available

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana 70808
    United States

    Site Not Available

  • Great Lakes Research Group, Inc.

    Bay City, Michigan 48706
    United States

    Site Not Available

  • Great Lakes Research Institute

    Southfield, Michigan 48075
    United States

    Site Not Available

  • StudyMetrix Research

    Saint Peters, Missouri 63303
    United States

    Site Not Available

  • StudyMetrix Research

    St. Peters, Missouri 63303
    United States

    Site Not Available

  • Las Vegas Endocrinology

    Henderson, Nevada 89074
    United States

    Site Not Available

  • Albany Medical College, Division of Community Endocrinology

    Albany, New York 12203
    United States

    Site Not Available

  • Albany Medical College, Division of Community EndocrinologyAlbany

    Albany, New York 12203
    United States

    Site Not Available

  • New York Gastroenterology Associates

    New York, New York 10075
    United States

    Site Not Available

  • New York Gastroenterology Associates Loc. 1

    New York, New York 10075
    United States

    Site Not Available

  • Westchester Medical Center

    Valhalla, New York 10595
    United States

    Site Not Available

  • PharmQuest Life Sciences, LLC

    Greensboro, North Carolina 27408
    United States

    Site Not Available

  • Monroe Biomedical Research

    Monroe, North Carolina 28112
    United States

    Site Not Available

  • Accellacare - Wilmington

    Wilmington, North Carolina 28401
    United States

    Site Not Available

  • Lillestol Research

    Fargo, North Dakota 58104
    United States

    Site Not Available

  • PriMED Clinical Research

    Dayton, Ohio 45429
    United States

    Site Not Available

  • Tribe Clinical Research, LLC

    Greenville, South Carolina 29607
    United States

    Site Not Available

  • WR-Clinsearch, LLC

    Chattanooga, Tennessee 37421
    United States

    Site Not Available

  • Headlands Horizons LLC

    Brownsville, Texas 78526
    United States

    Site Not Available

  • Houston Research Institute

    Houston, Texas 77079
    United States

    Site Not Available

  • Next Level Urgent Care

    Houston, Texas 77057
    United States

    Site Not Available

  • Consano Clinical Research, LLC

    Shavano Park, Texas 78231
    United States

    Site Not Available

  • Chrysalis Clinical Research

    Saint George, Utah 84790
    United States

    Site Not Available

  • Chrysalis Clinical Research

    St. George, Utah 84790
    United States

    Site Not Available

  • Charlottesville Medical Research

    Charlottesville, Virginia 22911
    United States

    Site Not Available

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