Greater Houston Area Pediatric Bipolar Registry

Inclusion Criteria for bipolar patients or offspring of bipolar parents:

• Any current mood state (in the case of bipolar subjects)

• For bipolar patients: DSM-V criteria for BD type I, BD type II, or BD NOS, as per the administration of the Mini International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)

• For the offspring of bipolar parents: at least one parent meeting DSM-V criteria for BD type I or BD type II, or BD NOS as per the administration of the MINI Adult

Exclusion Criteria for bipolar patients or offspring of bipolar parents:

• Autism Spectrum Disorder (ASD)

• Developmental Intellectual Disorder

• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

• Schizophrenia

• Uncontrolled or severe medical problem per investigator judgment

• For the offspring: parents with a history of any brain diseases, including seizures, stroke, meningitis, encephalitis, dementia, and other degenerative brain diseases; parents with a history of intellectual disability

Exclusion Criteria for healthy control subjects:

• Any Psychiatric Diagnosis

• Any family history of Bipolar Disorder, Psychotic Disorder, Schizophrenia, or Schizoaffective disorder in a first-degree relative

• Any family history of a neurological condition in a first-degree relative.

• Mental Retardation/Intellectual Disability

• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

• Schizophrenia

• Uncontrolled or severe medical problem per investigator judgement

Exclusion criteria for annual visits:

• Autism Spectrum Disorders (ASD)

• Intellectual Developmental Disorder

• Severe Neurological Disorder that affects cognitive status (e.g., epilepsy, traumatic brain injury, tubular sclerosis)

• Schizophrenia

• Uncontrolled or severe medical problem per investigator judgement