A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Last updated: February 19, 2026
Sponsor: Alnylam Pharmaceuticals
Overall Status: Active - Enrolling

Phase

3

Condition

Amyloidosis

Circulation Disorders

Treatment

Vutrisiran

Clinical Study ID

NCT06679946
ALN-TTRSC02-007
2024-516568-27
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who are participating in the patisiran parent studies ALN-TTR02-011 orALN-TTR02-014 or who have completed the 24-month OLE Period in the vutrisiran parentstudy ALN-TTRSC02-003

Exclusion

Exclusion Criteria:

  • Has permanently discontinued study drug administration while participating in theparent studies, ALN-TTR02-011, ALN-TTR02-014, or ALN-TTRSC02-003

  • Future or current participation in another investigational device or drug study,scheduled to occur during this study

  • Has other medical conditions or comorbidities which, in the opinion of theInvestigator, would interfere with study compliance or data interpretation

Study Design

Total Participants: 700
Treatment Group(s): 1
Primary Treatment: Vutrisiran
Phase: 3
Study Start date:
December 03, 2024
Estimated Completion Date:
March 31, 2028

Connect with a study center

  • Clinical Trial Site

    Buenos Aires,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Buenos Aires 3435910, C1428
    Argentina

    Site Not Available

  • Clinical Trial Site

    Córdoba,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Córdoba 3860259, X5000KEH
    Argentina

    Site Not Available

  • Clinical Trial Site

    Rosario,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Rosario 3838583, S2000DSR
    Argentina

    Site Not Available

  • Clinical Trial Site

    Vienna,
    Austria

    Site Not Available

  • Clinical Trial Site

    Vienna 2761369, 1090
    Austria

    Site Not Available

  • Clinical Trial Site

    Aalst,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Aalst 2803448, 9300
    Belgium

    Site Not Available

  • Clinical Trial Site

    Anderlecht,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Anderlecht 2803201, 1070
    Belgium

    Site Not Available

  • Clinical Trial Site

    Dendermonde,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Dendermonde 2799645, 9200
    Belgium

    Site Not Available

  • Clinical Trial Site

    Ghent,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Ghent 2797656, 9000
    Belgium

    Site Not Available

  • Clinical Trial Site

    Hasselt,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Hasselt 2796491, 3500
    Belgium

    Site Not Available

  • Clinical Trial Site

    Leuven,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Leuven 2792482, 3000
    Belgium

    Site Not Available

  • Clinical Trial Site

    Liège,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Liège 2792413, 4000
    Belgium

    Site Not Available

  • Clinical Trial Site

    Roeselare,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Roeselare 2787889, 8800
    Belgium

    Site Not Available

  • Clinical Trial Site

    Ribeirão Preto,
    Brazil

    Site Not Available

  • Clinical Trial Site

    Ribeirão Preto 3451328, 14026-900
    Brazil

    Site Not Available

  • Clinical Trial Site

    Rio de Janeiro,
    Brazil

    Site Not Available

  • Clinical Trial Site

    Rio de Janeiro 3451190, 22280-020
    Brazil

    Site Not Available

  • Clinical Trial Site

    São Paulo,
    Brazil

    Site Not Available

  • Clinical Trial Site

    São Paulo 3448439, 04012-180
    Brazil

    Site Not Available

  • Clinical Trial Site

    Prague,
    Czechia

    Site Not Available

  • Clinical Trial Site

    Prague 3067696, 140 21
    Czechia

    Site Not Available

  • Clinical Trial Site

    Aarhus,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Aarhus 2624652,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Aarhus N 11746890, 8200
    Denmark

    Site Not Available

  • Clinical Trial Site

    Copenhagen,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Copenhagen 2618425,
    Denmark

    Site Not Available

  • Clinical Trial Site

    København Ø 11746747, 2100
    Denmark

    Site Not Available

  • Clinical Trial Site

    Odense,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Odense 2615876,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Odense C 11746507, 5000
    Denmark

    Site Not Available

  • Clinical Trial Site

    Créteil,
    France

    Site Not Available

  • Clinical Trial Site

    Créteil 3022530, 94000
    France

    Site Not Available

  • Clinical Trial Site

    Marseille,
    France

    Site Not Available

  • Clinical Trial Site

    Marseille 2995469, 13005
    France

    Site Not Available

  • Clinical Trial Site

    Paris,
    France

    Site Not Available

  • Clinical Trial Site

    Paris 2988507, 75018
    France

    Site Not Available

  • Clinical Trial Site

    Rennes,
    France

    Site Not Available

  • Clinical Trial Site

    Rennes 2983990, 35000
    France

    Site Not Available

  • Clinical Trial Site

    Toulouse,
    France

    Site Not Available

  • Clinical Trial Site

    Toulouse 2972315, 31059
    France

    Site Not Available

  • Clinical Trial Site

    Bologna,
    Italy

    Site Not Available

  • Clinical Trial Site

    Bologna 3181928, 40138
    Italy

    Site Not Available

  • Clinical Trial Site

    Florence,
    Italy

    Site Not Available

  • Clinical Trial Site

    Florence 3176959, 50134
    Italy

    Site Not Available

  • Clinical Trial Site

    Pavia,
    Italy

    Site Not Available

  • Clinical Trial Site

    Pavia 3171366, 27100
    Italy

    Site Not Available

  • Clinical Trial Site

    Groningen,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Groningen 2755251, 9713 GZ
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Maastricht,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Maastricht 2751283, 6229 HX
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Utrecht,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Utrecht 2745912, 3584 CX
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Oslo,
    Norway

    Site Not Available

  • Clinical Trial Site

    Oslo 3143244, 372
    Norway

    Site Not Available

  • Clinical Trial Site

    Creixomil,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Creixomil 2740287, 4835-044
    Portugal

    Site Not Available

  • Clinical Trial Site

    Lisbon,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Lisbon 2267057, 1649-035
    Portugal

    Site Not Available

  • Clinical Trial Site

    Porto,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Porto 2735943, 4099-001
    Portugal

    Site Not Available

  • Clinical Trial Site

    Viseu,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Viseu 2732265, 3504-509
    Portugal

    Site Not Available

  • Clinical Trial Site

    Seoul 1835848, 03080
    South Korea

    Site Not Available

  • Clinical Trial Site

    Barcelona,
    Spain

    Site Not Available

  • Clinical Trial Site

    Barcelona 3128760, 08035
    Spain

    Site Not Available

  • Clinical Trial Site

    Bilbao,
    Spain

    Site Not Available

  • Clinical Trial Site

    Bilbao 3128026, 48013
    Spain

    Site Not Available

  • Clinical Trial Site

    L'Hospitalet de Llobregat 3120619, 8907
    Spain

    Site Not Available

  • Clinical Trial Site

    Llobregat,
    Spain

    Site Not Available

  • Clinical Trial Site

    Madrid 3117735, 28222
    Spain

    Site Not Available

  • Clinical Trial Site

    Majadahonda,
    Spain

    Site Not Available

  • Clinical Trial Site

    Majadahonda 3117667,
    Spain

    Site Not Available

  • Clinical Trial Site

    Málaga,
    Spain

    Site Not Available

  • Clinical Trial Site

    Málaga 2514256, 29010
    Spain

    Site Not Available

  • Clinical Trial Site

    Gothenburg, 413 45
    Sweden

    Site Not Available

  • Clinical Trial Site

    Gothenburg 2711537, 413 45
    Sweden

    Site Not Available

  • Clinical Trial Site

    Solna, 171 76
    Sweden

    Site Not Available

  • Clinical Trial Site

    Solna 2675397, 171 76
    Sweden

    Site Not Available

  • Clinical Trial Site

    Umeå, 901 85
    Sweden

    Site Not Available

  • Clinical Trial Site

    Umeå 602150, 907 37
    Sweden

    Site Not Available

  • Clinical Trial Site

    Taipei,
    Taiwan

    Site Not Available

  • Clinical Trial Site

    Taipei 1668341, 112
    Taiwan

    Site Not Available

  • Clinical Trial Site

    Bellshill, Scotland
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Bellshill 2655952, ML4 3NJ
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Birmingham,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Birmingham 2655603, B15 2SQ
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Cardiff,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Cardiff 2653822, CF15 9SS
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Hexham,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Hexham 2647007, NE46 1QJ
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    London,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    London 2643743, NW3 2QG
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Manchester,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Manchester 2643123, M15 6SE
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Phoenix, Arizona 85054
    United States

    Site Not Available

  • Clinical Trial Site

    Phoenix 5308655, Arizona 5551752 85054
    United States

    Site Not Available

  • Clinical Trial Site

    San Diego, California 92037
    United States

    Site Not Available

  • Clinical Trial Site

    Stanford, California 94305
    United States

    Site Not Available

  • Clinical Trial Site

    West Hollywood, California 90048
    United States

    Site Not Available

  • Clinical Trial Site

    Beverly Hills 5328041, California 5332921 90211
    United States

    Site Not Available

  • Clinical Trial Site

    La Jolla 5363943, California 5332921 92037
    United States

    Site Not Available

  • Clinical Trial Site

    San Diego 5391811, California 5332921 92037
    United States

    Site Not Available

  • Clinical Trial Site

    Stanford 5398563, California 5332921 94305
    United States

    Site Not Available

  • Clinical Trial Site

    West Hollywood 5408076, California 5332921 90048
    United States

    Site Not Available

  • Clinical Trial Site

    Washington, District of Columbia 20010
    United States

    Site Not Available

  • Clinical Trial Site

    Washington D.C. 4140963, District of Columbia 4138106 20010
    United States

    Site Not Available

  • Clinical Trial Site

    Chicago, Illinois 60637
    United States

    Site Not Available

  • Clinical Trial Site

    Chicago 4887398, Illinois 4896861 60637
    United States

    Site Not Available

  • Clinical Trial Site

    Glenview 4893886, Illinois 4896861 60026
    United States

    Site Not Available

  • Clinical Trial Site

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Clinical Trial Site

    Indianapolis 4259418, Indiana 4921868 46202
    United States

    Site Not Available

  • Clinical Trial Site

    Kansas City, Kansas 66103
    United States

    Site Not Available

  • Clinical Trial Site

    Kansas City 4273837, Kansas 4273857 66160
    United States

    Site Not Available

  • Clinical Trial Site

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Clinical Trial Site

    Baltimore 4347778, Maryland 4361885 21287
    United States

    Site Not Available

  • Clinical Trial Site

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Clinical Trial Site

    Boston 4930956, Massachusetts 6254926 02115
    United States

    Site Not Available

  • Clinical Trial Site

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Clinical Trial Site

    Rochester 5043473, Minnesota 5037779 55905
    United States

    Site Not Available

  • Clinical Trial Site

    Saint Louis, Missouri 63130
    United States

    Site Not Available

  • Clinical Trial Site

    St Louis 4407066, Missouri 4398678 63110
    United States

    Site Not Available

  • Clinical Trial Site

    Omaha, Nebraska 68198
    United States

    Site Not Available

  • Clinical Trial Site

    Omaha 5074472, Nebraska 5073708 68198
    United States

    Site Not Available

  • Clinical Trial Site

    New York, New York 10032
    United States

    Site Not Available

  • Clinical Trial Site

    New York 5128581, New York 5128638 10032
    United States

    Site Not Available

  • Clinical Trial Site

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Clinical Trial Site

    Durham 4464368, North Carolina 4482348 27710
    United States

    Site Not Available

  • Clinical Trial Site

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Clinical Trial Site

    Columbus, Ohio 43214
    United States

    Site Not Available

  • Clinical Trial Site

    Cleveland 5150529, Ohio 5165418 44195
    United States

    Site Not Available

  • Clinical Trial Site

    Columbus 4509177, Ohio 5165418 43214
    United States

    Site Not Available

  • Clinical Trial Site

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Clinical Trial Site

    Philadelphia 4560349, Pennsylvania 6254927 19104
    United States

    Site Not Available

  • Clinical Trial Site

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • Clinical Trial Site

    Nashville 4644585, Tennessee 4662168 37232
    United States

    Site Not Available

  • Clinical Trial Site

    Dallas, Texas 75246
    United States

    Site Not Available

  • Clinical Trial Site

    Houston, Texas 77030
    United States

    Site Not Available

  • Clinical Trial Site

    Dallas 4684888, Texas 4736286 75246
    United States

    Site Not Available

  • Clinical Trial Site

    Salt Lake City, Utah 84132
    United States

    Site Not Available

  • Clinical Trial Site

    Salt Lake City 5780993, Utah 5549030 84132
    United States

    Site Not Available

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