A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Last updated: January 17, 2025
Sponsor: Alnylam Pharmaceuticals
Overall Status: Active - Enrolling

Phase

3

Condition

Amyloidosis

Circulation Disorders

Treatment

Vutrisiran

Clinical Study ID

NCT06679946
ALN-TTRSC02-007
2024-516568-27
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to obtain safety, efficacy, and pharmacodynamic data on the use of vutrisiran in patients with ATTR amyloidosis with cardiomyopathy who continued on extended use of vutrisiran, or switched from patisiran.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients who are participating in the patisiran parent studies ALN-TTR02-011 orALN-TTR02-014 or who have completed the 24-month OLE Period in the vutrisiran parentstudy ALN-TTRSC02-003

Exclusion

Exclusion Criteria:

  • Has permanently discontinued study drug administration while participating in theparent studies, ALN-TTR02-011, ALN-TTR02-014, or ALN-TTRSC02-003

  • Future or current participation in another investigational device or drug study,scheduled to occur during this study

  • Has other medical conditions or comorbidities which, in the opinion of theInvestigator, would interfere with study compliance or data interpretation

Study Design

Total Participants: 800
Treatment Group(s): 1
Primary Treatment: Vutrisiran
Phase: 3
Study Start date:
December 03, 2024
Estimated Completion Date:
June 30, 2028

Connect with a study center

  • Clinical Trial Site

    Buenos Aires,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Córdoba,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Rosario,
    Argentina

    Site Not Available

  • Clinical Trial Site

    Vienna,
    Austria

    Site Not Available

  • Clinical Trial Site

    Aalst,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Anderlecht,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Dendermonde,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Ghent,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Hasselt,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Leuven,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Liège,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Roeselare,
    Belgium

    Site Not Available

  • Clinical Trial Site

    Ribeirão Preto,
    Brazil

    Site Not Available

  • Clinical Trial Site

    Rio de Janeiro,
    Brazil

    Site Not Available

  • Clinical Trial Site

    São Paulo,
    Brazil

    Site Not Available

  • Clinical Trial Site

    Prague,
    Czechia

    Site Not Available

  • Clinical Trial Site

    Aarhus,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Copenhagen,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Odense,
    Denmark

    Site Not Available

  • Clinical Trial Site

    Créteil,
    France

    Site Not Available

  • Clinical Trial Site

    Marseille,
    France

    Site Not Available

  • Clinical Trial Site

    Paris,
    France

    Site Not Available

  • Clinical Trial Site

    Rennes,
    France

    Site Not Available

  • Clinical Trial Site

    Toulouse,
    France

    Site Not Available

  • Clinical Trial Site

    Bologna,
    Italy

    Site Not Available

  • Clinical Trial Site

    Florence,
    Italy

    Site Not Available

  • Clinical Trial Site

    Pavia,
    Italy

    Site Not Available

  • Clinical Trial Site

    Groningen,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Maastricht,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Utrecht,
    Netherlands

    Site Not Available

  • Clinical Trial Site

    Oslo,
    Norway

    Site Not Available

  • Clinical Trial Site

    Creixomil,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Lisbon,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Porto,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Viseu,
    Portugal

    Site Not Available

  • Clinical Trial Site

    Barcelona,
    Spain

    Site Not Available

  • Clinical Trial Site

    Bilbao,
    Spain

    Site Not Available

  • Clinical Trial Site

    Llobregat,
    Spain

    Site Not Available

  • Clinical Trial Site

    Majadahonda,
    Spain

    Site Not Available

  • Clinical Trial Site

    Málaga,
    Spain

    Site Not Available

  • Clinical Trial Site

    Gothenburg, 413 45
    Sweden

    Site Not Available

  • Clinical Trial Site

    Solna, 171 76
    Sweden

    Site Not Available

  • Clinical Trial Site

    Umeå, 901 85
    Sweden

    Site Not Available

  • Clinical Trial Site

    Taipei,
    Taiwan

    Site Not Available

  • Clinical Trial Site

    Bellshill, Scotland
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Birmingham,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Cardiff,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Hexham,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    London,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Manchester,
    United Kingdom

    Site Not Available

  • Clinical Trial Site

    Phoenix, Arizona 85054
    United States

    Site Not Available

  • Clinical Trial Site

    San Diego, California 92037
    United States

    Site Not Available

  • Clinical Trial Site

    Stanford, California 94305
    United States

    Site Not Available

  • Clinical Trial Site

    West Hollywood, California 90048
    United States

    Site Not Available

  • Clinical Trial Site

    Washington, District of Columbia 20010
    United States

    Site Not Available

  • Clinical Trial Site

    Chicago, Illinois 60201
    United States

    Site Not Available

  • Clinical Trial Site

    Indianapolis, Indiana 46202
    United States

    Site Not Available

  • Clinical Trial Site

    Kansas City, Kansas 66103
    United States

    Site Not Available

  • Clinical Trial Site

    Baltimore, Maryland 21287
    United States

    Site Not Available

  • Clinical Trial Site

    Boston, Massachusetts 02215
    United States

    Site Not Available

  • Clinical Trial Site

    Rochester, Minnesota 55905
    United States

    Site Not Available

  • Clinical Trial Site

    Saint Louis, Missouri 63130
    United States

    Site Not Available

  • Clinical Trial Site

    Omaha, Nebraska 68198
    United States

    Site Not Available

  • Clinical Trial Site

    New York, New York 10032
    United States

    Site Not Available

  • Clinical Trial Site

    Durham, North Carolina 27710
    United States

    Site Not Available

  • Clinical Trial Site

    Cleveland, Ohio 44195
    United States

    Site Not Available

  • Clinical Trial Site

    Columbus, Ohio 43214
    United States

    Site Not Available

  • Clinical Trial Site

    Philadelphia, Pennsylvania 19104
    United States

    Site Not Available

  • Clinical Trial Site

    Nashville, Tennessee 37232
    United States

    Site Not Available

  • Clinical Trial Site

    Dallas, Texas 75246
    United States

    Site Not Available

  • Clinical Trial Site

    Houston, Texas 77030
    United States

    Site Not Available

  • Clinical Trial Site

    Salt Lake City, Utah 84132
    United States

    Site Not Available

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