A Study of BMS-986482 Alone or as Combination Therapy in Participants With Advanced Solid Tumors

Last updated: January 30, 2026
Sponsor: Bristol-Myers Squibb
Overall Status: Active - Recruiting

Phase

1/2

Condition

Neoplasms

Treatment

Nivolumab/relatlimab/rHuPH20

BMS-986482

Nivolumab and rHuPH20

Clinical Study ID

NCT06697197
CA236-0001
U1111-1309-0886
2024-516602-28
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to test the safety and efficacy of BMS-986482 alone and as combination therapy in participants with advanced solid tumors.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • All participants must have a histologically or cytologically confirmed, advanced,unresectable/metastatic, solid malignancy measurable by RECIST v1.1, and havereceived, be refractory to, ineligible for, intolerant of, or refused existingtherapy(ies) known to provide clinical benefit for the condition of the participant.

  • Participant must be ≥ 18 years or the legal age of consent in the jurisdiction inwhich the study is taking place, inclusive, at the time of signing the ICF.

Exclusion

Exclusion Criteria:

  • History of life threatening immune mediated toxicity related to prior T-cell agonistor checkpoint inhibitor therapy, except those that are unlikely to re-occur withstandard countermeasures.

  • Any significant acute or chronic medical illness which would interfere with studyintervention or follow-up in the opinion of the investigator.

  • Other protocol-defined Inclusion/Exclusion criteria apply.

Study Design

Total Participants: 413
Treatment Group(s): 4
Primary Treatment: Nivolumab/relatlimab/rHuPH20
Phase: 1/2
Study Start date:
February 17, 2025
Estimated Completion Date:
January 05, 2029

Connect with a study center

  • Local Institution - 0017

    Gent, Oost-Vlaanderen 9000
    Belgium

    Site Not Available

  • Local Institution - 0017

    Ghent 2797656, Oost-Vlaanderen 9000
    Belgium

    Site Not Available

  • UZ Gent

    Ghent 2797656, Oost-Vlaanderen 9000
    Belgium

    Active - Recruiting

  • Local Institution - 0022

    Copenhagen 2618425, Capital Region 6418538 DK-2100
    Denmark

    Site Not Available

  • Rigshospitalet

    Copenhagen 2618425, Capital Region 6418538 DK-2100
    Denmark

    Active - Recruiting

  • Local Institution - 0022

    Copenhagen, Hovedstaden DK-2100
    Denmark

    Site Not Available

  • Local Institution - 0016

    Marseille, Bouches-du-Rhône 13385
    France

    Site Not Available

  • Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone

    Marseille 2995469, Bouches-du-Rhône 13385
    France

    Active - Recruiting

  • Local Institution - 0016

    Marseille 2995469, Bouches-du-Rhône 13385
    France

    Site Not Available

  • Gustave Roussy

    Villejuif 2968705, Paris 94800
    France

    Active - Recruiting

  • Local Institution - 0012

    Villejuif, Val-de-Marne 94800
    France

    Site Not Available

  • Local Institution - 0012

    Villejuif 2968705, Val-de-Marne 94800
    France

    Site Not Available

  • Local Institution - 0038

    Athens, Attikí 11527
    Greece

    Site Not Available

  • General Hospital of Athens "Laiko"

    Athens 264371, Attikí 11527
    Greece

    Active - Recruiting

  • Local Institution - 0038

    Athens 264371, Attikí 11527
    Greece

    Site Not Available

  • Local Institution - 0039

    Thessaloniki, Thessaloníki 564 29
    Greece

    Site Not Available

  • Local Institution - 0039

    Thessaloniki 734077, Thessaloníki 564 29
    Greece

    Site Not Available

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki 734077, Thessaloníki 564 29
    Greece

    Active - Recruiting

  • Local Institution - 0037

    Milan, Lombardia 20133
    Italy

    Site Not Available

  • Fondazione IRCCS Istituto Nazionale dei Tumori

    Milan 3173435, Lombardy 3174618 20133
    Italy

    Active - Recruiting

  • Local Institution - 0037

    Milan 3173435, Lombardy 3174618 20133
    Italy

    Site Not Available

  • Local Institution - 0036

    Rozzano, Milano 20089
    Italy

    Site Not Available

  • Istituto Clinico Humanitas

    Rozzano 3168837, Milano 20089
    Italy

    Active - Recruiting

  • Local Institution - 0036

    Rozzano 3168837, Milano 20089
    Italy

    Site Not Available

  • Local Institution - 0018

    Amsterdam, Noord-Holland 1066 CX
    Netherlands

    Site Not Available

  • Local Institution - 0018

    Amsterdam 2759794, North Holland 2749879 1066 CX
    Netherlands

    Site Not Available

  • Nederlands Kanker Instituut Antoni van Leeuwenhoek (NKI AVL)

    Amsterdam 2759794, North Holland 2749879 1066 CX
    Netherlands

    Active - Recruiting

  • Local Institution - 0028

    Rotterdam, 3015 GD
    Netherlands

    Site Not Available

  • Erasmus Medisch Centrum

    Rotterdam 2747891, 3015 GD
    Netherlands

    Active - Recruiting

  • Local Institution - 0028

    Rotterdam 2747891, 3015 GD
    Netherlands

    Site Not Available

  • Local Institution - 0033

    Barcelona, Barcelona [Barcelona] 08035
    Spain

    Site Not Available

  • Hospital Universitari Vall d'Hebron

    Barcelona 3128760, Barcelona [Barcelona] 08035
    Spain

    Active - Recruiting

  • Local Institution - 0033

    Barcelona 3128760, Barcelona [Barcelona] 08035
    Spain

    Site Not Available

  • Local Institution - 0035

    Pamplona, Navarra 31008
    Spain

    Site Not Available

  • Clinica Universidad de Navarra

    Pamplona 3114472, Navarre 3115609 31008
    Spain

    Active - Recruiting

  • Local Institution - 0035

    Pamplona 3114472, Navarre 3115609 31008
    Spain

    Site Not Available

  • Local Institution - 0034

    Madrid, 28050
    Spain

    Site Not Available

  • Hospital Universitario HM Sanchinarro

    Madrid 3117735, 28050
    Spain

    Active - Recruiting

  • Local Institution - 0034

    Madrid 3117735, 28050
    Spain

    Site Not Available

  • Local Institution - 0023

    Solna, Stockholms Län [se-01] 171 64
    Sweden

    Site Not Available

  • Karolinska Universitetssjukhuset Solna

    Solna 2675397, Stockholms Län [se-01] 171 64
    Sweden

    Active - Recruiting

  • Local Institution - 0023

    Solna 2675397, Stockholms Län [se-01] 171 64
    Sweden

    Site Not Available

  • Local Institution - 0005

    Irvine, California 92612
    United States

    Site Not Available

  • Local Institution - 0030

    Los Angeles, California 90025
    United States

    Site Not Available

  • Local Institution - 0005

    Irvine 5359777, California 5332921 92612
    United States

    Site Not Available

  • University of California, Irvine (UCI) Health - UC Irvine Medical Center

    Irvine 5359777, California 5332921 92612
    United States

    Active - Recruiting

  • Local Institution - 0030

    Los Angeles 5368361, California 5332921 90025
    United States

    Site Not Available

  • The Angeles Clinic and Research Institute - West Los Angeles Office

    Los Angeles 5368361, California 5332921 90025
    United States

    Active - Recruiting

  • Local Institution - 0008

    Aurora, Colorado 80045
    United States

    Site Not Available

  • Local Institution - 0008

    Aurora 5412347, Colorado 5417618 80045
    United States

    Site Not Available

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack, New Jersey 07601
    United States

    Site Not Available

  • Local Institution - 0009

    Hackensack, New Jersey 07601
    United States

    Site Not Available

  • John Theurer Cancer Center at Hackensack University Medical Center

    Hackensack 5098706, New Jersey 5101760 07601
    United States

    Active - Recruiting

  • Local Institution - 0007

    Lake Success, New York 11042
    United States

    Site Not Available

  • Northwell Health/ RJ Zuckerberg Cancer Center

    Lake Success, New York 11042
    United States

    Site Not Available

  • Northwell Health/ RJ Zuckerberg Cancer Center

    Lake Success 5123853, New York 5128638 11042
    United States

    Active - Recruiting

  • Levine Cancer Institute

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Local Institution - 0011

    Charlotte, North Carolina 28204
    United States

    Site Not Available

  • Levine Cancer Institute

    Charlotte 4460243, North Carolina 4482348 28204
    United States

    Active - Recruiting

  • Fred Hutchinson Cancer Center

    Seattle, Washington 98109
    United States

    Site Not Available

  • Local Institution - 0010

    Seattle, Washington 98109
    United States

    Site Not Available

  • Fred Hutchinson Cancer Center

    Seattle 5809844, Washington 5815135 98109
    United States

    Active - Recruiting

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