YN001-004 in Patients With Coronary Atherosclerosis in Australia

Inclusion Criteria:

1. Fully understand the purposes, features, and methods of the study, and sign the ICFbefore performing any assessment.

2. Male or female Australia patients between 18 and 75 years.

3. Patients diagnosed with coronary atherosclerosis, and at least 1 vessel withdiameter stenosis determined by coronary computed tomography angiography (CTA).

4. Female patients must be non-pregnant and non-lactating, and females of childbearingpotential (including a female partner of a male patient) must agree to use 1effective contraception method from the screening period to 3 months after receivingtheir last dose of the study drug. In addition, male patients must be willing torefrain from sperm donation during this time.

5. Willing and able to comply with the requirements of protocol to the best of thepatient's and investigator's knowledge.

Exclusion Criteria:

1. Prior treatment with other investigational drug(s) within 30 days or 5 half-lives,whichever is longer, prior to randomization.

2. Previously received YN001.

3. Any type of vaccination within 4 weeks prior to randomization.

4. Contraindication for coronary CTA (e.g., known history of anaphylactic contrastreactions).

5. Multi-vessel severe disease.

6. Recent acute ST-segment elevation myocardial infarction (STEMI) occurred within 2weeks prior to randomization.

7. Relapse and highly symptomatic arrhythmia uncontrolled by drugs within the past 3months, such as ventricular tachycardia, atrial fibrillation with rapid ventricularrate and paroxysmal supraventricular tachycardia.

8. Prior treatment with CABG, heart transplantation, SAVR/TAVR, etc., or CABG, hearttransplantation, SAVR/TAVR, etc., is required or planned during the study.

9. PCI performed within 4 weeks prior to randomization or PCI is required or plannedduring study treatment.

10. New York Heart Association (NYHA) class III or IV, or last known left ventricularejection fraction (LVEF) <40%.

11. Recent clinically evident stroke occurred within 6 months prior to randomization (except for TIA).

12. Presenting with history of myopathy/myalgia, or susceptible tomyopathy/rhabdomyolysis.

13. Known inflammatory bowel disease, ulcers, gastrointestinal or rectal bleeding within 6 months prior to randomization.

14. Evidence of major diseases that not recovered within 2 weeks prior to randomization,or major surgery is expected during the study.

15. Presenting with history of malignancy (except in patients who have been disease-free >5 years; or whose only malignancy has been basal or squamous cell skin carcinoma).

16. Presence of any type of autoimmune disease.

17. Allergy to multiple food or drugs or known sensitivity to any components to beadministered during dosing

18. Life expectancy is less than 1 year.

19. Systolic blood pressure of ≥150 mmHg at final screening despite antihypertensivetherapy.

20. Known familial hypercholesterolemia

21. Triglycerides≥400 mg/dl (4.5 mmol/l) at final screening.

22. Active liver disease or hepatic dysfunction defined by any of ALT, AST, or totalbilirubin > 2 times upper limit of normal (ULN) at final screening.

23. Presence of renal insufficiency.

24. Untreated or inadequately treated hypothyroidism defined by thyroid stimulatinghormone (TSH) > 1.5 times ULN at final screening.

25. Poorly controlled (defined by HbA1c > 9%) type 2 diabetes mellitus.

26. A positive hepatitis B surface antigen (HBsAg), or positive antibody againsthepatitis C virus (anti-HCV) or human immunodeficiency virus (anti-HIV), or positivetreponema pallidum antibody (TP-Ab).

27. Current smoker who has smoked an average of≥5 cigarettes (or equivalent) per dayover the preceding year.

28. Presence of any other diseases or conditions (apart from those outlined above) that,in the opinion of the investigator, would make it unsuitable for the patient toparticipate in this study.