Intravenous Thrombolysis and NOAC

Inclusion Criteria:

1. Patients with clinical signs of acute ischemic stroke within 24 hours of onset orawakening with stroke (if within 24 hours from the midpoint of sleep). Patients withAIS within 4.5-24 hours of onset must meet the IVT inclusion criteria specified inthe guideline

2. Patients with new oral anticoagulants usage within 4-48 hours of onset;

3. Patients ≥ 18 years old

4. Informed consent has been obtained depending on local ethics requirements.

Exclusion Criteria:

1. Intended to proceed to endovascular treatment

2. With APTT >40s

3. Pre-stroke mRS score > 2

4. Contraindications for IVT：

1. Intracranial hemorrhage (including parenchymal hemorrhage, intraventricularhemorrhage, subarachnoid hemorrhage, epidural hematoma, etc.) 2) Previous history ofintracranial hemorrhage 3) Severe head trauma or stroke history within the last 3months 4) Intracranial tumors, giant intracranial aneurysms 5) Intracranial orspinal surgery within the recent 3 months 6) Major surgical procedures within thelast 2 weeks 7) Gastrointestinal or urinary tract bleeding within the last 3 weeks
2. Active visceral bleeding 9) Aortic arch dissection 10) Arterial puncture in asite within the last 1 week that is not easy to compress and stop bleeding 11)Elevated blood pressure: Systolic blood pressure ≥ 180 mmHg or diastolic bloodpressure ≥ 100 mmHg 12) Acute bleeding tendency, including platelet count < 100 × 10⁹/L or other conditions 13) Received low-molecular-weight heparin treatment within 24 hours 14) Oral anticoagulants (warfarin) with INR > 1.7 or PT > 15 s 15) Bloodsugar < 2.8 or > 22.22 mmol/L 16) Head CT or MRI indicates large-area infarction (infarction area ≥ 1/3 of the middle cerebral artery supply area) (4) The judgmentis left to the discretion of the investigator