Electroacupuncture Treatment of Peripheral Neuropathy After Taxane Chemotherapy for Breast Cancer

Last updated: January 12, 2025
Sponsor: Affiliated Hospital of Qinghai University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Neurologic Disorders

Breast Cancer

Cancer

Treatment

Electro-acupuncture

Clinical Study ID

NCT06772935
AHQU-2025001
  • Ages 18-75
  • Female

Study Summary

Electroacupuncture treatment of peripheral neuropathy after taxane chemotherapy for breast cancer

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Breast cancer patients diagnosed by pathology;

  • EOOG score is 0 or 1;

  • The age range for enrollment is between 18 and 75 years old; ④ Acceptchemotherapy regimens based on taxane drugs (alone or in combination); ⑤ Previously received taxane chemotherapy for more than 6 months; ⑥ According to the National Cancer Institute (NCI) Common Terminology forAdverse Events (CTCAE) 5.0, reporting CIPN symptoms of grade 1 or higherfor more than 2 weeks; ⑦ Voluntarily participate in this clinical trial and sign the informedconsent form;

  • Accept regular follow-up visits; ⑨ There is complete pathologicaldata available.

Exclusion

Exclusion Criteria:

  • Non breast cancer patients;

  • Received electroacupuncture treatment within 6 months prior to the start of thestudy;

  • Patients who experience intolerable toxic side effects during standarddose chemotherapy and terminate the chemotherapy cycle;

  • Prior to enrollment, there was a history of peripheral neuropathy;

  • Unstable heart disease or myocardial infarction within the first 6 months of the study; ⑥ Active skin diseases or surface skin ulcers or infections thatcannot tolerate electroacupuncture treatment; ⑦ Uncontrolled epilepsy patients with uncontrolled seizures; ⑧ Merge with other malignant tumor patients; ⑨ Pregnancy and lactation period; ⑩ Refusal to join clinical trial patients

Study Design

Total Participants: 162
Treatment Group(s): 1
Primary Treatment: Electro-acupuncture
Phase:
Study Start date:
June 01, 2025
Estimated Completion Date:
December 31, 2027

Study Description

Chemotherapy induced peripheral neuropathy has a significant impact on the integrity of chemotherapy cycle and quality of life of breast cancer patients. The latest research reports indicate that electroacupuncture has a certain therapeutic effect on peripheral neuropathy. In addition, existing studies have confirmed that the peripheral neuropathy of breast cancer induced by taxane is related to genetic factors. This study is based on electroacupuncture treatment of peripheral neuropathy induced by paclitaxel drugs, while screening SNPs related to peripheral neuropathy induced by taxane drugs, and establishing a prognostic model. Eligible patients diagnosed as stage I, II or IIIA breast cancer with peripheral neuropathy for at least 2 weeks were assessed by functional cancer treatment assessment/gynecological oncology group neurotoxicity scale (FACT/GOG-NTX) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire CIPN Twenty Item Scale (EORTC QLQ-CIPN20). All items in the above two scales are scored using Likert's 5 and 4 levels. The researchers will temporarily divide the study into two groups, and if necessary, the researchers will add this group. Laboratory personnel are unaware of all clinical and outcome data.

Connect with a study center

  • Qinghai University Affiliated Hospital

    Xining, Qinghai 810001
    China

    Active - Recruiting

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