Real-time Neurofeedback Training of the Medial Prefrontal Cortex Based on Positive Episodic Future Thinking

Last updated: January 15, 2025
Sponsor: University of Electronic Science and Technology of China
Overall Status: Active - Recruiting

Phase

N/A

Condition

Habit Reversal

Treatment

real-time fMRI sham-controlled neurofeedback training procedure

Clinical Study ID

NCT06787248
BAM_lab_NF_05
  • Ages 18-35
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Randomized active-sham controlled between-subject real-time fMRI neurofeedback trial aiming to modulate activity in the medial prefrontal cortex (mPFC) to improve subjective positive anticipation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy subjects without any past or present psychiatric or neurological disorders

Exclusion

Exclusion Criteria:

  • History of brain injury

  • Psychiatric or Neurological Disorder

  • Contraindications for MRI

  • Regular use of psychotropic substances (medication, drugs)

Study Design

Total Participants: 60
Treatment Group(s): 1
Primary Treatment: real-time fMRI sham-controlled neurofeedback training procedure
Phase:
Study Start date:
January 01, 2025
Estimated Completion Date:
July 01, 2027

Study Description

A randomized double-blind sham-controlled between-subject design using real-time fMRI neurofeedback. In a randomized order, a total of 60 healthy subjects will be recruited and assigned (1) experimental group (EG; N=30), which receives real neurofeedback from the left medial prefrontal cortex (mPFC), or (2) control group (CG; N=30) which receives sham neurofeedback from the primary motor cortex (M1). Neurofeedback training consists of 1 baseline session without feedback, 4 training sessions with real-time feedback, and and 1 transfer session without feedback. Resting state fMRI will be employed to explore neural effects. Objectives are to determine (1) if subjects in the neurofeedback (NF) group can gain volitional control over the mPFC activation using positive episodic regulation strategy, (2) whether successful increased modulation of the mPFC could enhance positive anticipation for future events and motivation (using the Effort-Expenditure for Reward Task, EEfRT).

Connect with a study center

  • University of Electronic Science and Technology of China(UESTC)

    Chengdu, Sichuan 611731
    China

    Active - Recruiting

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