A Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Related Macular Degeneration

Inclusion Criteria:

• Overtly healthy as determined by medical evaluation that includes medical historyand physical examination

• Agreement to adhere to the contraception requirements described in the protocol

Ocular Inclusion Criteria for Study Eye:

• Active treatment-naïve macular neovascularization (MNV) secondary to age-relatedmacular degeneration (AMD), confirmed by the investigator based on the presence ofintraretinal fluid (IRF) or subretinal fluid (SRF) affecting the central subfield onoptical coherence tomography (OCT)

• BCVA of 83 to 24 letters, inclusive (20/25 to 20/320 approximate Snellen equivalent,using the early treatment diabetic retinopathy study [ETDRS] protocol and addressedat the initial testing distance of 4 meters on Day 1)

• Sufficiently clear ocular media and adequate pupillary dilation to allow acquisitionof good quality retinal images to confirm diagnosis

Exclusion Criteria:

Ocular Exclusion Criteria for Study Eye:

• MNV due to causes other than nAMD, such as ocular histoplasmosis, trauma,pathological myopia, angioid streaks, choroidal rupture, or uveitis

• Retinal pigment epithelial tear involving the macula on Day 1

• Current vitreous hemorrhage on Day 1

• Prior periocular pharmacological or IVT treatment (including faricimab,anti-vascular endothelial growth factor [VEGF], or complement inhibitor medication)for other retinal diseases

Ocular Exclusion Criteria for Fellow (Non-Study) Eye:

• Participants who have a nonfunctioning fellow (non-study) eye, defined as eitherBCVA of hand motion or worse, or no physical presence of non-study eye (i.e.,monocular), at both the screening and study Day 1 visits

Ocular Exclusion for Both Eyes:

• History of idiopathic or autoimmune associated uveitis in either eye

• Active ocular inflammation or suspected or active ocular or periocular infection ineither eye on study Day 1