A Study to Learn About How the Flu and COVID-19 Vaccines Act in Healthy People

Last updated: January 23, 2026
Sponsor: BioNTech SE
Overall Status: Completed

Phase

1/2

Condition

Covid-19

Influenza

Treatment

Investigational COVID-19 Vaccine

Licensed Influenza Vaccine 2

Licensed COVID-19 Vaccine

Clinical Study ID

NCT06821061
C6271001
C6271001-C1
C6271001-C1A
  • Ages > 18
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The purpose of this study is to learn about how the flu and COVID vaccines act when given alone or when mixed together.

This study is seeking healthy participants aged 18 or older. All participants in this study will receive only 1 shot to their arm, either a flu or COVID vaccine, alone or mixed. Participants will take part in this study for about 6 months, and participants will need to visit the clinical study site at least 4 times.

Eligibility Criteria

Inclusion

Inclusion criteria:

  • Participants 18 years of age or older

  • Healthy participants who are determined by medical history, physical examination (ifclinically required), and clinical judgement of the investigator to be eligible forinclusion in the study

Exclusion

Exclusion criteria:

  • Vaccination with any investigational or licensed influenza vaccine within 150 daysof enrollment

  • Vaccination with any investigational or licensed COVID 19 vaccine within 150 days ofenrollment.

  • Receipt of antiviral therapies for influenza (eg, Tamiflu) within 180 days prior toDay 1.

Refer to the study contact for further eligibility details

Study Design

Total Participants: 2650
Treatment Group(s): 7
Primary Treatment: Investigational COVID-19 Vaccine
Phase: 1/2
Study Start date:
February 10, 2025
Estimated Completion Date:
December 17, 2025

Connect with a study center

  • Anaheim Clinical Trials, LLC

    Anaheim, California 92801
    United States

    Site Not Available

  • Orange County Research Center

    Lake Forest, California 92630
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    Riverside, California 92503
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego, California 92103
    United States

    Site Not Available

  • Diablo Clinical Research, Inc.

    Walnut Creek, California 94598
    United States

    Site Not Available

  • Anaheim Clinical Trials, LLC

    Anaheim 5323810, California 5332921 92801
    United States

    Site Not Available

  • Orange County Research Center

    Lake Forest 5364514, California 5332921 92630
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    Riverside 5387877, California 5332921 92503
    United States

    Site Not Available

  • Artemis Institute for Clinical Research

    San Diego 5391811, California 5332921 92103
    United States

    Site Not Available

  • Diablo Clinical Research, Inc.

    Walnut Creek 5406990, California 5332921 94598
    United States

    Site Not Available

  • Clinical Research Consulting

    Milford, Connecticut 06460
    United States

    Site Not Available

  • Clinical Research Consulting

    Milford 4838652, Connecticut 4831725 06460
    United States

    Site Not Available

  • Alliance for Multispecialty Research, LLC

    Coral Gables, Florida 33134
    United States

    Site Not Available

  • Indago Research & Health Center, Inc

    Hialeah, Florida 33012
    United States

    Site Not Available

  • Miami Dade Medical Research Institute, LLC

    Miami, Florida 33176
    United States

    Site Not Available

  • Palm Springs Community Health Center

    Miami Lakes, Florida 33014
    United States

    Site Not Available

  • Alliance for Multispecialty Research, LLC

    Doral 4153471, Florida 4155751 33172
    United States

    Site Not Available

  • Indago Research & Health Center, Inc

    Hialeah 4158476, Florida 4155751 33012
    United States

    Site Not Available

  • Miami Dade Medical Research Institute, LLC

    Miami 4164138, Florida 4155751 33176
    United States

    Site Not Available

  • Palm Springs Community Health Center

    Miami Lakes 4164186, Florida 4155751 33014
    United States

    Site Not Available

  • Clinical Research Atlanta

    Stockbridge, Georgia 30281
    United States

    Site Not Available

  • Clinical Research Atlanta

    Stockbridge 4224681, Georgia 4197000 30281
    United States

    Site Not Available

  • East-West Medical Research Institute

    Honolulu, Hawaii 96814
    United States

    Site Not Available

  • East-West Medical Research Institute

    Honolulu 5856195, Hawaii 5855797 96814
    United States

    Site Not Available

  • Clinical Research Professionals

    Chesterfield, Missouri 63005
    United States

    Site Not Available

  • Clinical Research Professionals

    Chesterfield 4381072, Missouri 4398678 63005
    United States

    Site Not Available

  • Las Vegas Clinical Trials

    North Las Vegas, Nevada 89030
    United States

    Site Not Available

  • Las Vegas Clinical Trials

    North Las Vegas 5509403, Nevada 5509151 89030
    United States

    Site Not Available

  • Upstate Global Health Institute

    East Syracuse, New York 13057
    United States

    Site Not Available

  • University of Rochester Medical Center

    Rochester, New York 14642
    United States

    Site Not Available

  • Upstate Global Health Institute

    East Syracuse 5116079, New York 5128638 13057
    United States

    Site Not Available

  • University of Rochester Medical Center

    Rochester 5134086, New York 5128638 14642
    United States

    Site Not Available

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington, North Carolina 28403
    United States

    Site Not Available

  • Trial Management Associates - Wilmington - Floral Parkway

    Wilmington 4499379, North Carolina 4482348 28403
    United States

    Site Not Available

  • Centricity Research Columbus Ohio Multispecialty

    Columbus, Ohio 43213
    United States

    Site Not Available

  • Centricity Research Columbus Ohio Multispecialty

    Columbus 4509177, Ohio 5165418 43213
    United States

    Site Not Available

  • DM Clinical Research - Philadelphia

    Philadelphia, Pennsylvania 19107
    United States

    Site Not Available

  • DM Clinical Research - Philadelphia

    Philadelphia 4560349, Pennsylvania 6254927 19107
    United States

    Site Not Available

  • Coastal Carolina Research Center

    North Charleston, South Carolina 29405
    United States

    Site Not Available

  • Coastal Carolina Research Center

    North Charleston 4589387, South Carolina 4597040 29405
    United States

    Site Not Available

  • AMR Clinical

    Knoxville, Tennessee 37920
    United States

    Site Not Available

  • Clinical Research Associates Inc

    Nashville, Tennessee 37203
    United States

    Site Not Available

  • AMR Clinical

    Knoxville 4634946, Tennessee 4662168 37909
    United States

    Site Not Available

  • Clinical Research Associates Inc

    Nashville 4644585, Tennessee 4662168 37203
    United States

    Site Not Available

  • Headlands Horizons, LLC dba Headlands Research-Brownsville

    Brownsville, Texas 78526
    United States

    Site Not Available

  • DM Clinical Research- Cyfair

    Houston, Texas 77065
    United States

    Site Not Available

  • SMS Clinical Research

    Mesquite, Texas 75149
    United States

    Site Not Available

  • Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball, Texas 77375
    United States

    Site Not Available

  • Headlands Horizons, LLC dba Headlands Research-Brownsville

    Brownsville 4676740, Texas 4736286 78526
    United States

    Site Not Available

  • DM Clinical Research- Cyfair

    Houston 4699066, Texas 4736286 77065
    United States

    Site Not Available

  • SMS Clinical Research

    Mesquite 4710826, Texas 4736286 75149
    United States

    Site Not Available

  • Dynamed Clinical Research, LP d/b/a DM Clinical Research

    Tomball 4737094, Texas 4736286 77375
    United States

    Site Not Available

  • J. Lewis Research, Inc. / Foothill Family Clinic

    Salt Lake City, Utah 84109
    United States

    Site Not Available

  • J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City, Utah 84121
    United States

    Active - Recruiting

  • J. Lewis Research, Inc. / Foothill Family Clinic

    Salt Lake City 5780993, Utah 5549030 84109
    United States

    Site Not Available

  • J. Lewis Research, Inc. / Foothill Family Clinic South

    Salt Lake City 5780993, Utah 5549030 84121
    United States

    Site Not Available

  • Charlottesville Medical Research

    Charlottesville, Virginia 22911
    United States

    Site Not Available

  • Charlottesville Medical Research

    Charlottesville 4752031, Virginia 6254928 22911
    United States

    Site Not Available

  • Kaiser Permanente Washington Health Research Institute (KPWHRI)

    Seattle, Washington 98101
    United States

    Site Not Available

  • Kaiser Permanente Washington Health Research Institute (KPWHRI)

    Seattle 5809844, Washington 5815135 98101
    United States

    Site Not Available

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