A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00006)

Inclusion Criteria:

1. ≥40 to ≤80 years old

2. COPD diagnosis ≥1 year,

3. Post-BD FEV1 ≥ 20% and ≤ 70% PN, FEV1/FVC <0.70 at screening

4. Triple (ICS+LABA+LAMA) or dual inhaled COPD therapy, if triple therapy is considerednot appropriate, ≥3 consecutive months prior to V1

5. ≥2 moderate or ≥1 severe COPD exacerbations in the prior year; At least 1 of 2moderate exacerbations must require the use of systemic corticosteroids. At leastone of the previous exacerbations should be confirmed to have occurred while theparticipant was on triple or dual inhaled maintenance therapy

6. EOS ≥ 150 cells/μL during screening

7. CAT ≥15 at screening

8. Former or current smokers ≥10 pack-years

Exclusion Criteria:

1. Clin. important pulmonary disease or radiological findings suggestive of arespiratory disease other than COPD

2. Asthma, incl. pediatric, or ACOS

3. Any unstable disorder that can impact participants safety or study outcomes

4. Tuberculosis requiring treatment within 12 months prior V2

5. Malignancies current or past Concomitant therapies:

• Macrolides (less than 6 months)

• Systemic immuno-suppressive, -modulating medications

6. LTOT >4.0 L/min or O2 saturation <89% despite LTOT