Phase
Condition
Chronic Bronchitis
Bronchiectasis
Emphysema
Treatment
Placebo
Tezepelumab
Clinical Study ID
Ages 40-80 All Genders
Study Summary
Eligibility Criteria
Inclusion
Inclusion Criteria:
≥40 to ≤80 years old
COPD diagnosis ≥1 year,
Post-BD FEV1 ≥ 20% and ≤ 70% PN, FEV1/FVC <0.70 at screening
Triple (ICS+LABA+LAMA) or dual inhaled COPD therapy ≥3 consecutive months prior toV1
≥2 moderate or ≥1 severe COPD exacerbations in the prior year; At least 1 of 2moderate exacerbations must require the use of systemic corticosteroids
EOS ≥ 150 cells/μL during screening
CAT ≥15 at screening
Former or current smokers ≥10 pack-years
Exclusion
Exclusion Criteria:
Clin. important pulmonary disease or radiological findings suggestive of arespiratory disease other than COPD
Asthma, incl. pediatric, or ACOS
Any unstable disorder that can impact participants safety or study outcomes
Tuberculosis requiring treatment within 12 months prior V2
Malignancies current or past Concomitant therapies:
Macrolides (less than 6 months)
Systemic immuno-suppressive, -modulating medications
- LTOT >4.0 L/min or O2 saturation <89% despite LTOT
Study Design
Study Description
Connect with a study center
Research Site
Bragança Paulista, 12916-542
BrazilSite Not Available
Research Site
Brasilia, 70200-730
BrazilSite Not Available
Research Site
Campinas, 13060-080
BrazilSite Not Available
Research Site
Chapeco, 89812-210
BrazilSite Not Available
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Curitiba, 80030-110
BrazilSite Not Available
Research Site
Jaú, 17201-130
BrazilSite Not Available
Research Site
Mossoro, 59603-020
BrazilSite Not Available
Research Site
Porto Alegre, 90480-000
BrazilSite Not Available
Research Site
Salvador, 40050-410
BrazilSite Not Available
Research Site
Sao Jose Do Rio Preto, 15090-000
BrazilSite Not Available
Research Site
Vitoria, 29062-110
BrazilSite Not Available
Research Site
Votuporanga, 15501-405
BrazilSite Not Available
Research Site
Calgary, Alberta T3B 0M3
CanadaSite Not Available
Research Site
Vancouver, British Columbia V5Z 1M9
CanadaSite Not Available
Research Site
Ajax, Ontario L1S 2J5
CanadaSite Not Available
Research Site
Burlington, Ontario L7N 3V2
CanadaSite Not Available
Research Site
Toronto, Ontario M5T 3A9
CanadaSite Not Available
Research Site
Winchester, Ontario K0C 2K0
CanadaSite Not Available
Research Site
Windsor, Ontario N8X-5A6
CanadaSite Not Available
Research Site
Montreal, Quebec H1T 2M4
CanadaSite Not Available
Research Site
St Charles Borromee, Quebec J6E 2B4
CanadaActive - Recruiting
Research Site
Trois-Rivières, Quebec G8T 7A1
CanadaActive - Recruiting
Research Site
Saskatoon, Saskatchewan S7N 0W8
CanadaSite Not Available
Research Site
Quebec, G1G 3Y8
CanadaActive - Recruiting
Research Site
Curico, 3341643
ChileSite Not Available
Research Site
Quillota, 2260000
ChileSite Not Available
Research Site
Santiago, 7501126
ChileSite Not Available
Research Site
Talca, 3481349
ChileSite Not Available
Research Site
Anyang, 455099
ChinaSite Not Available
Research Site
Changchun, 130021
ChinaSite Not Available
Research Site
Changsha, 410015
ChinaSite Not Available
Research Site
Chengdu, 611130
ChinaSite Not Available
Research Site
Chongqing, 401320
ChinaSite Not Available
Research Site
Fuzhou, 350031
ChinaSite Not Available
Research Site
Guangzhou, 510150
ChinaSite Not Available
Research Site
Haikou, 570311
ChinaSite Not Available
Research Site
Hangzhou, 310005
ChinaSite Not Available
Research Site
Hefei, 230061
ChinaSite Not Available
Research Site
Hengyang City, 421001
ChinaSite Not Available
Research Site
Heze, 274099
ChinaSite Not Available
Research Site
Hohhot, 750306
ChinaSite Not Available
Research Site
Huizhou, 516002
ChinaSite Not Available
Research Site
Jinan, 250013
ChinaSite Not Available
Research Site
Jinhua, 321000
ChinaSite Not Available
Research Site
Linhai, 317000
ChinaSite Not Available
Research Site
Nan Chong, 637000
ChinaSite Not Available
Research Site
Nanchang, 330006
ChinaSite Not Available
Research Site
Nanjing, 211100
ChinaSite Not Available
Research Site
Nanning, 530021
ChinaSite Not Available
Research Site
Pingxiang, 337055
ChinaSite Not Available
Research Site
Qingdao, 266011
ChinaSite Not Available
Research Site
Sanya, 572000
ChinaSite Not Available
Research Site
Shanghai, 200040
ChinaSite Not Available
Research Site
Shenyang, 110004
ChinaSite Not Available
Research Site
Shenzhen, 518020
ChinaSite Not Available
Research Site
Shijiazhuang, 50051
ChinaSite Not Available
Research Site
Suining Shi, 629000
ChinaSite Not Available
Research Site
Taiyuan, 030032
ChinaSite Not Available
Research Site
Taizhou, 318000
ChinaSite Not Available
Research Site
Tianjin, 300050
ChinaSite Not Available
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Wenzhou, 325027
ChinaSite Not Available
Research Site
Wuhan, 430022
ChinaSite Not Available
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Xinxiang, 453100
ChinaSite Not Available
Research Site
Xuzhou, 221000
ChinaSite Not Available
Research Site
Yangzhou, 225001
ChinaSite Not Available
Research Site
Yinchuan, 750004
ChinaSite Not Available
Research Site
Zhangzhou, 363099
ChinaSite Not Available
Research Site
Brandys nad Labem, 250 01
CzechiaSite Not Available
Research Site
Brno, 625 00
CzechiaSite Not Available
Research Site
Jindrichuv Hradec, 377 01
CzechiaSite Not Available
Research Site
Lovosice, 410 02
CzechiaSite Not Available
Research Site
Ostrava, 700 30
CzechiaSite Not Available
Research Site
Plzen, 301 00
CzechiaSite Not Available
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Praha 1, 110 00
CzechiaSite Not Available
Research Site
Praha 16, 15300
CzechiaSite Not Available
Research Site
Teplice, 415 01
CzechiaSite Not Available
Research Site
Varnsdorf, 407 47
CzechiaSite Not Available
Research Site
København NV, 2400
DenmarkSite Not Available
Research Site
Bendorf, 56170
GermanySite Not Available
Research Site
Berlin, 10787
GermanySite Not Available
Research Site
Haltern Am See, 45721
GermanySite Not Available
Research Site
Hannover, D-30173
GermanySite Not Available
Research Site
Immenhausen, 34376
GermanySite Not Available
Research Site
Lübeck, 23552
GermanySite Not Available
Research Site
Marburg, 35037
GermanySite Not Available
Research Site
Rosenheim, 83022
GermanySite Not Available
Research Site
Stuttgart, 70376
GermanySite Not Available
Research Site
Wiesbaden, 65183
GermanySite Not Available
Research Site
Ahmedabad, 380053
IndiaSite Not Available
Research Site
Belagavi, 590010
IndiaSite Not Available
Research Site
Coimbatore, 641028
IndiaSite Not Available
Research Site
Dehradun, 248001
IndiaSite Not Available
Research Site
Delhi, 110029
IndiaSite Not Available
Research Site
Faridabad, 121012
IndiaSite Not Available
Research Site
Gurgaon, 122001
IndiaSite Not Available
Research Site
Kochi, 682027
IndiaSite Not Available
Research Site
Kolkata, 700053
IndiaSite Not Available
Research Site
Lucknow, 226003
IndiaSite Not Available
Research Site
Madurai, 625107
IndiaSite Not Available
Research Site
Mysuru, 570002
IndiaSite Not Available
Research Site
Nagpur, 441108
IndiaSite Not Available
Research Site
Pune, 411 018
IndiaSite Not Available
Research Site
Vadodara, 391760
IndiaSite Not Available
Research Site
Firenze, 50134
ItalySite Not Available
Research Site
Milan, 20122
ItalySite Not Available
Research Site
Montebelluna, 31044
ItalySite Not Available
Research Site
Napoli, 80131
ItalySite Not Available
Research Site
Pavia, 27100
ItalySite Not Available
Research Site
Roma, 00128
ItalySite Not Available
Research Site
Sassari, 07100
ItalySite Not Available
Research Site
Telese Terme, 82037
ItalySite Not Available
Research Site
Tradate, 21049
ItalySite Not Available
Research Site
Anyang-si, 14068
Korea, Republic ofSite Not Available
Research Site
Daegu, 42415
Korea, Republic ofSite Not Available
Research Site
Iksan-si, 54538
Korea, Republic ofSite Not Available
Research Site
Jeonju, 54907
Korea, Republic ofSite Not Available
Research Site
Seoul, 150-713
Korea, Republic ofSite Not Available
Research Site
Uijeongbu-si, 11765
Korea, Republic ofSite Not Available
Research Site
Wonju-si, 26426
Korea, Republic ofSite Not Available
Research Site
Alor Setar, 5460
MalaysiaSite Not Available
Research Site
Kajang, 43000
MalaysiaSite Not Available
Research Site
Kota Kinabalu, 88200
MalaysiaSite Not Available
Research Site
Kuala Lumpur, 50603
MalaysiaSite Not Available
Research Site
Kuala Terengganu, 20400
MalaysiaSite Not Available
Research Site
Kuantan, 25100
MalaysiaSite Not Available
Research Site
Kuching, 93586
MalaysiaSite Not Available
Research Site
Benito Juarez, 03650
MexicoSite Not Available
Research Site
Chihuahua, 31000
MexicoSite Not Available
Research Site
Cuauhtémoc, 06700
MexicoSite Not Available
Research Site
Cuernavaca, 62290
MexicoSite Not Available
Research Site
Guadalajara, 44130
MexicoSite Not Available
Research Site
Merida, 97130
MexicoSite Not Available
Research Site
Monterrey, 64465
MexicoSite Not Available
Research Site
Morelia, 58000
MexicoSite Not Available
Research Site
Oaxaca, 68020
MexicoSite Not Available
Research Site
San Juan del Rio, 76800
MexicoSite Not Available
Research Site
Tijuna, 22010
MexicoSite Not Available
Research Site
Veracruz, 91900
MexicoSite Not Available
Research Site
Zapopan, 45138
MexicoSite Not Available
Research Site
Iloilo, 5000
PhilippinesSite Not Available
Research Site
Iloilo City, 5000
PhilippinesSite Not Available
Research Site
Las Pinas, 1742
PhilippinesSite Not Available
Research Site
Manadaluyong City, 1552
PhilippinesSite Not Available
Research Site
Manila, 1000
PhilippinesSite Not Available
Research Site
Marilao, 3019
PhilippinesSite Not Available
Research Site
Quezon City, 1100
PhilippinesSite Not Available
Research Site
Tondo, 1012
PhilippinesSite Not Available
Research Site
Białystok, 15-044
PolandSite Not Available
Research Site
Bydgoszcz, 85-231
PolandSite Not Available
Research Site
Chrzanów, 32-500
PolandSite Not Available
Research Site
Grodzisk Mazowiecki, 05-825
PolandSite Not Available
Research Site
Karczew, 05-480
PolandSite Not Available
Research Site
Katowice, 40-648
PolandSite Not Available
Research Site
Kielce, 25-426
PolandSite Not Available
Research Site
Kraków, 31-419
PolandSite Not Available
Research Site
Lodz, 91-211
PolandSite Not Available
Research Site
Lublin, 20-011
PolandSite Not Available
Research Site
Ostróda, 14-100
PolandSite Not Available
Research Site
Piaseczno, 05-500
PolandSite Not Available
Research Site
Poznań, 60-693
PolandSite Not Available
Research Site
Płock, 09-407
PolandSite Not Available
Research Site
Humenne, 066 01
SlovakiaSite Not Available
Research Site
Košice, 04011
SlovakiaSite Not Available
Research Site
Levice, 93401
SlovakiaSite Not Available
Research Site
Martin, 03659
SlovakiaSite Not Available
Research Site
Barakaldo, 48903
SpainSite Not Available
Research Site
Barcelona, 08036
SpainSite Not Available
Research Site
Granada, 18014
SpainSite Not Available
Research Site
Madrid, 28007
SpainSite Not Available
Research Site
Málaga, 29010
SpainSite Not Available
Research Site
Palma de Mallorca, 07010
SpainSite Not Available
Research Site
Pamplona, 31008
SpainSite Not Available
Research Site
Sevilla, 41013
SpainSite Not Available
Research Site
Valencia, 46010
SpainSite Not Available
Research Site
Bradford, BD9 6RJ
United KingdomSite Not Available
Research Site
Brighton, BN2 1ES
United KingdomSite Not Available
Research Site
Cottingham, HU16 5JQ
United KingdomSite Not Available
Research Site
Glasgow, G12 0YN
United KingdomSite Not Available
Research Site
Halifax, HX3 0PW
United KingdomSite Not Available
Research Site
Leeds, LS9 7TF
United KingdomSite Not Available
Research Site
Portsmouth, PO6 3LY
United KingdomSite Not Available
Research Site
Tyne And Wear, NE29 8NH
United KingdomSite Not Available
Research Site
Wakefield, WF1 4DG
United KingdomSite Not Available
Research Site
Sheffield, Alabama 35660
United StatesSite Not Available
Research Site
Tucson, Arizona 85704
United StatesSite Not Available
Research Site
Newport Beach, California 92663
United StatesSite Not Available
Research Site
Cutler Bay, Florida 33157
United StatesSite Not Available
Research Site
DeBary, Florida 32713
United StatesSite Not Available
Research Site
Homestead, Florida 33032
United StatesSite Not Available
Research Site
Miami, Florida 33125
United StatesSite Not Available
Research Site
Orlando, Florida 32807
United StatesSite Not Available
Research Site
Tampa, Florida 33607
United StatesSite Not Available
Research Site
Rincon, Georgia 31326
United StatesSite Not Available
Research Site
Evanston, Illinois 60208
United StatesSite Not Available
Research Site
Winfield, Illinois 60190
United StatesSite Not Available
Research Site
Columbia, Maryland 21045
United StatesSite Not Available
Research Site
North Dartmouth, Massachusetts 02747
United StatesSite Not Available
Research Site
Farmington Hills, Michigan 48336
United StatesActive - Recruiting
Research Site
Missoula, Montana 59808
United StatesSite Not Available
Research Site
Papillion, Nebraska 68046
United StatesSite Not Available
Research Site
Toms River, New Jersey 08755
United StatesSite Not Available
Research Site
Buffalo, New York 14215
United StatesSite Not Available
Research Site
Cortland, New York 13045
United StatesSite Not Available
Research Site
Horseheads, New York 14845
United StatesSite Not Available
Research Site
High Point, North Carolina 27260
United StatesActive - Recruiting
Research Site
New Bern, North Carolina 28562
United StatesSite Not Available
Research Site
Wilmington, North Carolina 28401
United StatesSite Not Available
Research Site
Winston-Salem, North Carolina 27103
United StatesSite Not Available
Research Site
Dublin, Ohio 43016
United StatesSite Not Available
Research Site
Oklahoma City, Oklahoma 73120
United StatesSite Not Available
Research Site
Philadelphia, Pennsylvania 19140
United StatesSite Not Available
Research Site
Rock Hill, South Carolina 29732
United StatesSite Not Available
Research Site
Franklin, Tennessee 37067
United StatesSite Not Available
Research Site
Johnson City, Tennessee 37601
United StatesSite Not Available
Research Site
Houston, Texas 77084
United StatesSite Not Available
Research Site
Kerrville, Texas 78028
United StatesSite Not Available
Research Site
Mansfield, Texas 76063
United StatesSite Not Available
Research Site
Cudahy, Wisconsin 53110
United StatesSite Not Available
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