Do you take opioids to treat your chronic pain?

Phase

N/A

Condition

Pain

Treatment

N/A

Clinical Study ID

TX154673

Ages 18-65
All Genders

Study Summary

Researchers at the MGH Center for Translational Pain Research are seeking participants for a 4-week study on chronic pain management.

The purpose of this study is to determine whether the study drug, guanfacine, in combination with an opioid medication can help reduce pain and reverse the indications of opioid-induced hyperalgesia (OIH) in chronic pain patients. Sometimes long-term opioid therapy leads to an increased sensitivity to pain, this condition is known as OIH.

Eligibility Criteria

Inclusion

You may be eligible for this study if:

• You are between 18 and 65 years of age.

• You have chronic neck or back pain.

• You have been taking opioid medications (such as Percocet, Dilaudid, Vicodin, Kadian, MS Contin, OxyContin, etc.) for at least 3 months.

• You are able to read and respond to questions in English.

Study Design

Study Description

The study will consist of 4 office visits and 2 phone calls. Participants will be randomly assigned to receive either guanfacine or placebo. Participants will be asked to provide one blood sample, multiple urine samples for drug screen analysis, fill out questionnaires, and undergo sensitivity tests to hot and cold temperatures using an FDA approved machine. Participants will be compensated up to $190 upon completion of the study.

If you are interested in hearing more about this study, please contact Olivia:

617-724-6102

MGHPainResearch@partners.org

<http://www.massgeneral.org/translationalpainresearch/>