A research study for people with severe asthma

Inclusion Criteria:

• Have you had asthma for at least two years, with a documented diagnosis of severe asthma?
• Have you been taking either mepolizumab/benralizumab and a inhaled corticosteriod for at least 12 months?
• If you are a woman cof child bearing potential are you willing to take, for the duration of the study and 4 weeks post treatment, a highly effective contraceptive?

Exclusion Criteria:

• Do you currently have any other clinically significant lung condition other than asthma? Such as current infection, bronchiectasis, pulmonary fibrosis, bronchopulmonary aspergillosis, or diagnoses of emphysema or chronic bronchitis (chronic obstructive pulmonary disease other than asthma) or a history of lung cancer.
• Do you currently have Eosinophilic Diseases, that could lead to elevated eosinophils such as hyper-eosinophilic syndromes including (but not limited to) Eosinophilic Granulomatosis with Polyangiitis (EGPA, formerly known as Churg-Strauss Syndrome) or Eosinophilic Esophagitis.
• Have you taken within the last 130 days other mAbs used in the treatment of asthma? Such as omalizumab (Xolair), dupilumab (Dupixent) or reslizumab (Cinqair/Cinqaero).